Ionizing radiation-induced mutagenesis

Ionizing radiation-induced mutagenesis in Isaria fumosorosea

Ionizing Radiation Induced Radicals

When ionizing radiation passes through a material it imparts some of its energy to that material. The imparted energy may be high enough to cause a break in bonds inside the molecules or between molecules or both, in such cases, free radicals are created. The type, lifetime, extent, fate and origin of those free radicals may differ according to several factors; most of them are beyond the subje...

RBE-LET relationships in mutagenesis by ionizing radiation.

The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and Drosophila melanogaster. Experimental data are presented for the relative biological effectiveness of helium ions and alpha-partic...

Mutational Analysis of Ionizing Radiation Induced Neoplasms.

Ionizing radiation (IR) is a mutagen that promotes tumorigenesis in multiple exposure contexts. One severe consequence of IR is the development of second malignant neoplasms (SMNs), a radiotherapy-associated complication in survivors of cancers, particularly pediatric cancers. SMN genomes are poorly characterized, and the influence of genetic background on genotoxin-induced mutations has not be...

Genomic instability induced by ionizing radiation.

Genomic instability is characterized by the increased rate of acquisition of alterations in the mammalian genome. These changes encompass a diverse set of biological end points including karyotypic abnormalities, gene mutation and amplification, cellular transformation, clonal heterogeneity and delayed reproductive cell death. The loss of stability of the genome is becoming accepted as one of t...